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. De Bus et al. Beta-lactam antibiotics. De-escalation is considered to be one of the strategies to reduce overall exposure to broad-spectrum antibiotics and.Bacterial resistance to antibiotics has become a major public health. (overexpression of broad-spectrum ß-lactamases together with efflux. Ampicillin Sulbactam.. recevant des antibiotiques de large spectre ou après une chirurgie étendue,. caractérisée par une résistance à l'ampicilline et à la céfalotine.. but also improving our ability to avoid administering unnecessary broad-spectrum antibiotics,. Appropriate antibiotic stewardship in ICUs includes not only.
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